巴西专利BR112012000937B1 connecting device

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专利摘要:
Connecting device The present invention relates to a device capable of preventing an operation of establishing communication between a syringe (2, 102) and a vial (3, 103) from being forgotten by mistake. the retaining means (4, 104) which constitutes a connection device (1,101, 201) includes: a syringe retaining member (6, 106, 206) to be connected to a syringe (2, 102); a cannula retaining member (7, 107, 207) which includes a double head cannula (5, 105, 205), is located in a retracted position, retracted from the syringe retaining member (6, 106, 206) in the pre-use state, and is advanced to an advanced position by touching the syringe retaining member (6, 106, 206) in the state of use; and the separation prevention means (42, 142) that engages the syringe (2, 102) to prevent the separation of the syringe (2, 102) from the syringe retaining member (6, 106, 206) in the state where the cannula retaining member (7, 107, 207) is located in the retracted position. when the cannula retaining member (7, 107, 207) is located in the forward position, the separation prevention means (42, 142) releases a state of engagement with the syringe (2, 102) to allow separation of the syringe (2, 102) of the syringe retaining member (6, 106, 206).
公开号:BR112012000937B1
申请号:R112012000937
申请日:2010-07-12
公开日:2020-04-07
发明作者:Kubo Tomohiko
申请人:Nipro Corp；
IPC主号:

专利说明:

[0001] The present invention relates to a connection device, and specifically to a connection device capable of connecting a pre-use state, in which the syringe and vial are spaced from each other, and a cannula of double head does not penetrate the syringe and bottle cap members, for a state of use where the syringe and vial are placed close together and the double head cannula penetrates the cap members.
BACKGROUND OF THE TECHNIQUE [0002] A connecting device connecting from a pre-use state, in which a syringe and vial are spaced from each other and the double-head cannula does not penetrate the syringe and vial cap members to a state of use in which the syringe and the vial are placed close together and a double-headed cannula penetrates the members of the syringe cap and the vial to establish communication between the internal spaces of the syringe and the vial, is conventionally known.
[0003] As such a connection device, a connection device in which the syringe and the vial are connected to both ends of the cylindrical retention medium and the double head cannula is provided within the retention medium to be movable (PTL 1 ).
[0004] According to the connection device, placing the syringe close to the vial maintained by the retention means, the double-head cannula can penetrate the syringe and vial cap members to establish communication between their internal spaces.
CITATION LIST
PATENT LITERATURE
Petition 870190102962, of 10/14/2019, p. 4/39
2/25 [0005] PTL 1: Japanese Patent Open to Public Inspection No.
2007-260162.
SUMMARY OF THE INVENTION
TECHNICAL PROBLEM [0006] However, the PTL 1 connection device is configured such that the holding means and the syringe are merely provided to be slidable, and the syringe can be separated from the holding means at any time.
[0007] Therefore, there is a possibility that a user may erroneously separate the syringe from the retention medium without establishing a communication between the syringe and the vial, and the use of the syringe without mixing a solution inside the syringe with a medication inside the vial. .
[0008] In view of such a problem, an objective of the present invention is to provide a connection device that prevents an operation of establishing communication between the syringe and the vial from being forgotten by mistake.
TROUBLESHOOTING [0009] Specifically, a connection device according to claim 1 is a connection device that includes the holding means by distancing a syringe and vial from one another or placing the syringe and vial next to each other, and a double-headed cannula provided between the cap members connected to the syringe and the vial to penetrate the cap members, the connection device changing from a pre-use state in which the retaining means separates the syringe and the vial one on the other and the double-head cannula does not penetrate the cap members of a syringe and vial, to a state of use in which the holding medium places the syringe and vial next to each other and the double-head cannula penetrates syringe and bottle cap members to establish communication
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3/25 between the inner spaces of a syringe and the vial, where the holding means is composed of a syringe holding member to be attached to the syringe, and a cannula holding member including the double-headed cannula, is located in a retracted stowed position with respect to the syringe holding member in the pre-used state, and is advanced to an advanced position by touching the syringe holding member in the used state, the separation prevention means that engages the syringe to prevent separation of the syringe from the syringe holding member in the state where the cannula holding member is located in the retracted position is still provided, and, when the cannula holding member is located in the forward position, the means of prevention Separation system releases a state of engagement with the syringe to allow separation of the syringe from the syringe retaining member.
ADVANTAGE EFFECTS OF THE INVENTION [00010] According to the invention described above, since the separation prevention means prevents the syringe from being separated from the syringe retaining member in the pre-use state, the connection device can prevent a user forgetting to perform an operation to establish communication between the syringe and the vial.
BRIEF DESCRIPTION OF THE DRAWINGS [00011] Figure 1 is a cross-sectional view of a connection device according to the present embodiment.
[00012] Figure 2 is a cross-sectional view taken along a portion II-II in Figure 1.
[00013] Figure 3 is a perspective view of the connection device.
[00014] Figure 4 is a view showing the operation of the connection device.
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4/25 [00015] Figure 5 is a view showing the operation of the connection device seen differently from that in figure 4.
[00016] Figure 6 is a cross-sectional view of a connection device according to a second embodiment.
[00017] Figure 7 is a view showing the operation of the connection device according to the second mode.
[00018] Figure 8 is a view showing a connection device according to a third modality, and the operation thereof. DESCRIPTION OF THE MODALITIES [00019] Hereinafter, a connection device 1 according to a first modality will be described. Figures 1 and 2 show cross-sectional views of the connection device 1 according to the first embodiment. Figure 3 shows a perspective view of the connection device 1, and figures 4 and 5 are views that illustrate a method of using the connection device 1 in the cross sectional views shown in figures 1 and 2, respectively.
[00020] The connection device 1 includes the retaining means 4 that holds a syringe 2 and a vial 3, and a double head cannula 5 provided between the syringe 2 and the vial 3 to establish the communication between the internal spaces of the syringe 2 and vial 3.
[00021] Retention means 4 is composed of a syringe retention member 6 to be connected to syringe 2, and a cannula retention member 7 that includes double head cannula 5. Syringe retention member 6 and the cannula retaining member 7 is provided to be able to be advanced and retracted (i.e., moving back and forth) in an up and down direction in Figure 1.
[00022] According to the connection device 1 that has such a configuration, in a connection state shown in Figures 4 (b) and 5 (b), the cannula retaining member 7 is located in a
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5/25 second retracted position located behind relative to the syringe retaining member 6.
[00023] Next, in a pre-use state shown in Figures 4 (c) and 5 (c), the cannula retaining member 7 is located in a first forward retracted position from the second retracted position, and the double head 5 is located so as not to establish communication between the internal spaces of syringe 2 and vial 3.
[00024] Next, in a state of use shown in Figures 4 (e) and 5 (e), the cannula retaining member 7 moves to an advanced position in contact with the syringe retaining member 6, and the double head cannula 5 is located to establish communication between the internal spaces of syringe 2 and vial 3.
[00025] It should be noted that in the following description an axial direction refers to a direction parallel to a central axis of the syringe 2, advanced refers to an upward direction in Figure 1, that is, a direction in which the vial 3 approaches of syringe 2, and delayed refers to a downward direction in Figure 1, that is, a direction in which vial 3 is distanced from syringe 2.
[00026] Syringe 2 is made up of a barrel 11 that stores the solution, and a plunger not shown advanced and retracted within barrel 11. A connection portion 12 to which a cannula not shown will be attached is provided at a tip end from barrel 11.
[00027] The connecting portion 12 is composed of a hollow tapered portion 12a in communication with the interior of the barrel 11, and a cylindrical portion 12b provided to surround the tapered portion 12a. An external thread portion 12c is formed on an outer periphery of the cylindrical portion 12b.
[00028] In addition, grooves 12d are formed in the external thread portion 12c in an advanced-delayed direction, in opposite positions with the central axis being interspersed between them. Thus, the
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6/25 portion of external thread 12c is interrupted and discontinuous (Figure 4 (a)). [00029] Additionally, a rubber cap member 13 is attached to the tapered portion 12a. The cap member 13 is composed of a small diameter portion 13a that covers the tapered portion 12a and has a smaller diameter than that of the cylindrical portion 12b, and a large diameter portion 13b with a large diameter provided at a tip end of small diameter portion 13a. The wide diameter portion 13b has a thin center.
[00030] Vial 3 is composed of a glass bottle portion 21 that stores a medication, a rubber cap member 22 attached to an opening of the bottle portion 21, and a metal ring member 23 that holds the member cap 22 to the bottle portion 21.
[00031] The flange portion 21a having a diameter substantially identical to that of the cap member 22 is formed at the opening of the bottle portion 21, and the cap member 22 is formed to have a thin center. The ring member 23 surrounds the flange portion 21a and the cap member 22 to integrally secure them, such that a thin portion of the cap member 22 is exposed.
[00032] The syringe retaining member 6 is composed of an outer cylindrical portion 31 in the shape of a cylinder provided to cover the cannula retaining member 7, and a connecting portion 32 which has a smaller diameter than that of the outer cylindrical portion 31 and must be connected with the connecting portion 12 of the syringe 2. A step difference portion 33 is formed between the outer cylindrical portion 31 and the connecting portion 32. The outer cylindrical portion 31 includes four tabs 31b made through four slits formed in the forward-backward direction. The guide projections 34 are formed on a pair of front flaps 31b in the forward-backward direction, and the stop projections 35 are formed in an arc shape near the rear end portions of another pair of flaps
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Front 7/25 31b.
An inner peripheral surface of the connecting portion 32 has a diameter substantially identical to that of an outer peripheral surface of the cylindrical portion 12b of the syringe 2. An inner thread portion 32a within which the outer thread portion 12c formed in the cylindrical portion 12b should be screwed is formed on the inner peripheral surface of the connecting portion 32.
[00033] Additionally, the grooves 32b are formed in the internal thread portion 32a in the forward-backward direction, in opposite positions with the central axis being interspersed between them. In this way, the internal thread portion 32a is interrupted and discontinuous.
[00034] The grooves 12d in the outer thread portion 12c formed in the syringe 2 and the grooves 32b in the inner thread portion 32a are formed to have an identical width, and provided such that the grooves 12d and 32b overlap when the thread portion outer 12c is screwed into the internal thread portion 32a.
[00035] The cannula retaining member 7 includes an inner cylindrical portion 41 in the shape of a bottom cylinder having the double head cannula 5 provided in the center, and the separation prevention means 42 that prevents the separation of the syringe 2 from the syringe retaining member 6 in the pre-use state.
[00036] The double-head cannula 5 is composed of a cannula on the side of syringe 5a next to syringe 2, and a cannula on the side of vial 5b next to vial 3. A channel 5c is formed within the cannula on the side of syringe 5a and the cannula on the side of the vial 5b.
[00037] The tip of the cannula on the side of the syringe 5a is formed in a conical shape, and the channel 5c is opened on the lateral surfaces of the cannula on the side of the syringe 5a. On the other hand, the tip end of the cannula on the side of the vial 5b is formed obliquely as shown in Figure 1, and the channel 5c is opened behind a portion
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8/25 sharp tip end.
[00038] Additionally, the cannula on the side of syringe 5a is thinner than the cannula on the side of vial 5b, and the puncture resistance obtained when the cannula on the side of syringe 5a penetrates the cap member 13 of syringe 2 is less than the puncture resistance obtained when the cannula on the side of the vial 5b penetrates the cap member 22 of the vial 3.
[00039] The inner cylindrical portion 41 has an outer diameter substantially identical to an inner diameter of the outer cylindrical portion 31 of the syringe retaining member 6, and has an inner diameter substantially identical to an outer diameter of the flange portion 21a of the vial 3 .
[00040] In addition, four flaps 41a are formed on the inner cylindrical portion 41, in positions identical to those on the outer cylindrical portion 31. On each flap 41a corresponding to the flap 31a having a guide ridge 34 formed thereon in the outer cylindrical portion 31, a guide groove 43 in which the guide projection 34 will engage is formed on an outer peripheral surface thereof.
[00041] By engaging the guide projections 34 in the guide slots 43, the rotation of the syringe retaining member 6 and the cannula retaining member 7 is restricted and its forward and retracted movement in the forward-delayed direction is permitted.
[00042] On the other hand, on each flap 41a that corresponds to flap 31b having stop protrusion 35 formed thereon in an outer cylindrical portion 31, stop grooves 44 in which stop protrusion 35 will engage are formed on an outer peripheral surface thereof , in two positions in the forward-backward direction, and a retaining protrusion 45 in the retaining bottle 3 is formed on an inner peripheral surface thereof.
[00043] Stop grooves 44 are formed in positions where the
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9/25 stop protrusion 35 engages the same respectively when the cannula retaining member 7 is located in the second retracted position and in the first retracted position with respect to the syringe retaining member 6.
[00044] In the pre-use state shown in Figures 4 (c) and 5 (c), retaining projections 45 touch an end surface of the vial 3 on the side closest to the syringe 2, such that the head cannula double 5 is located in a position where it does not penetrate the cap member 22 of the bottle 3.
[00045] On the other hand, when the vial 3 is relatively advanced with respect to the pre-use state, the ring member 23 of the vial 3 pushes the retaining projections 45 outwards, and after that it is kept between a bottom portion of the inner cylindrical portion 41 and the retaining projections 45, and at the same time the double-head cannula 5 penetrates the cap member 22 of the bottle 3, entering the post-use state shown in Figures 4 (e) and 5 (e ).
[00046] The separation prevention means 42 is composed of two inserts 42a provided in opposite positions with the cannula on the side of the syringe 5a in the inner cylindrical portion 41 being interspersed between them, the partial thread portions 42b provided on the sides inner ends of insert points 42a, and the stop members 42c provided closer to the inner cylindrical portion 41 than the partial thread portions 42b.
[00047] Insertion pieces 42a are formed in positions and formed to have a width that allows insertion pieces 42a to slide along the grooves 32b formed in the internal thread portion 32a in connection portion 32 of the syringe retaining member
6. Insert parts 42a have internal surfaces with a diameter identical to that of the inner peripheral surface of the connecting portion 32. [00048] Partial thread portions 42b have a continuous shape
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10/25 to the internal thread portion 32a. When the partial thread portions 42b are aligned with the inner thread portion 32a as shown in Figure 4 (e), the inner thread portion 32a interrupted by 32b are lightly connected by the partial thread portions 42b.
[00049] Stop members 42c are elastically deformable, thin plate-like members, and are provided in positions where the stop members 42c engage the cap member 13 of syringe 2 on a side close to the syringe 2 in the post-use state .
[00050] Hereinafter, the method of using connection device 1 having the above configuration will be described with reference to the drawings in Figures 4 and 5.
[00051] Firstly, Figures 4 (a) and 5 (a) show a state of assembly of the connection device 1. On this occasion, syringe 2 and vial 3 are not connected to connection device 1.
[00052] Here, an operation of inserting the inner cylindrical portion 41 of the cannula holding member 7 into the outer cylindrical portion 31 of the syringe holding member 6 and the stopping cannula holding member 7 in the second retracted position.
[00053] Specifically, the positions of guide projections 34 formed on an inner peripheral surface of the outer cylindrical portion 31 are caused to engage the guide grooves 43 formed on an outer peripheral surface of the inner cylindrical portion 41, and the cannula retaining member 7 is inserted into the syringe retaining member 6.
[00054] Then, the stop projections 35 formed on the inner peripheral surface of the outer cylindrical portion 31 engage the stop grooves 44 located next to the syringe 2, of stop grooves 44 formed on the outer peripheral surface of the inner cylindrical portion 41. Thus , the cannula retaining member 7 is stopped in the second retracted position.
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11/25 [00055] On the other hand, when the cannula retaining member 7 is inserted in the second retracted position, insertion parts 42a of the separation prevention means 42 are inserted into the grooves 32b in the connecting portion 32 of the retaining member syringe 6, and the partial thread portions 42b are located behind the inner thread portion 32a.
[00056] Next, Figures 4 (b) and 5 (b) show the connection state in which the syringe 2 is connected to the connection device 1. This operation is performed by a medication manufacturer or similar, and an operation by a doctor is not required.
[00057] Here, a screwing operation of the external thread portion 12c formed in the connection portion 12 of the syringe 2 in the internal thread portion 32a in the connection portion 32 of the syringe retaining member 6 is performed.
[00058] As a result, when the outer thread portion 12c is completely screwed into the inner thread portion 32a, grooves 12d formed in the outer thread portion 12c overlap the grooves 32b formed in the inner thread portion 32a.
[00059] On the other hand, since the partial thread portions 42b of the separation prevention means 42 are located behind the inner thread portion 32a, partial thread portions 42b do not interfere with the outer thread portion 12c of syringe 2, and do not prevent syringe 2 from being screwed onto syringe retaining member 6.
[00060] Next, Figures 4 (c) and 5 (c) show the pre-use state in which the connection device 1 having the syringe 2 connected to it is fitted in the bottle 3. The connection device 1 in the pre-condition is provided for a medical purpose.
[00061] To change from a connection state to a pre-use state, it is only necessary to advance the cannula retaining member 7 from the second retracted position to the first retracted position with
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12/25 with respect to the syringe retaining member 6, and make the vial 3 touch the retaining projections 45 of the cannula retaining member 7.
[00062] When the cannula retaining member 7 is advanced to the first retracted position, the cannula on the syringe side 5a of the double head cannula 5 is advanced to a position where it does not penetrate the cap member 13 of syringe 2, and the partial thread portions 42b of the separation prevention means 42 are stopped in the misaligned positions with respect to the internal thread portion 32a.
[00063] As a result, if an attempt is made to rotate the syringe 2 and the syringe holding member 6 in the pre-used state, the outer thread portion 12c of syringe 2 interferes with the partial thread portions 42b. Thus, rotation of the syringe 2 and the syringe holding member 6 is prevented, and the syringe 2 cannot be separated from the syringe holding member 6.
[00064] Next, Figures 4 (d) and 5 (d) show a penetrated state on the side of the syringe in which syringe 2 and vial 3 are placed close together and the cannula on the side of syringe 5a penetrates the cap member 13 of syringe 2.
[00065] It should be noted that the current operation can proceed from the pre-use state in Figures 4 (c) and 5 (c) to the state of use in Figures 4 (e) and 5 (e) without stopping, and has no to be stopped in the state in Figures 4 (d) and 5 (d).
[00066] When syringe 2 and vial 3 are placed next to each other, the cannula retaining member 7 is pressed by vial 3 and tries to move to the forward position, and vial 3 tries to pass over the retaining projections 45 of the cannula retaining member 7 and moves forward.
[00067] Here, since the cannula on the syringe side 5a is thinner and has a lower puncture resistance than the cannula on the side of the syringe
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13/25 vial 5b, and the resistive force that allows vial 3 to pass over the retaining projections 45 is required, the cannula retaining member 7 first moves to the forward position with respect to the syringe retaining member 6, and cannula on the syringe side 5a penetrates the cap member 13 of syringe 2.
[00068] It should be noted that, on this occasion, the cannula on the side of the vial 5b can penetrate the cap member 22 before the cannula on the syringe side 5a penetrates the cap member 13 of the syringe 2.
[00069] Subsequently, Figures 4 (e) and 5 (e) show the state of use in which syringe 2 and vial 3 are still placed next to each other from the state penetrated on the side of the syringe and communication is established between the internal spaces of syringe 2 and vial 3.
[00070] When vial 3 is still advanced from the penetrated state on the side of the syringe in Figures 4 (d) and 5 (d), vial 3 presses the retaining projections 45 outwards, and thus the flaps 31a of the limb of cannula retention 7 and the flaps 41a of the syringe retention member 6 are integrally deformed to allow passage of the vial 3.
[00071] Next, the ring member 23 of the vial 3 passes over the retaining projections 45 and abuts the bottom portion of the inner cylindrical portion 41. Thus, the vial 3 is held by the retaining projections 45 so as not to be detached from the cannula retaining member 7, and the lower ends of the flaps 41a engage the stop projections 35 to prevent retraction of the cannula retaining member 7.
[00072] On the other hand, as the vial 3 is advanced, the cannula on the vial side 5b of the double-headed cannula 5 penetrates the cap member 22 of the vial 3, and thus communication is established between the internal space syringe 2 and the inner space of the vial 3.
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14/25 [00073] Here, since the double head cannula 5 penetrates the cap member 13 on the side of syringe 2 in advance and penetrates the cap member 22 of vial 3 hereinafter, the solution inside syringe 2 can be taken into vial 3 having negative pressure.
[00074] After entering the state of use, a user performs an operation to operate the syringe 2 to inject the solution into the bottle 3 to dissolve the medicine into the bottle 3 with the solution, and then take the dissolved medicine back to inside the syringe 2.
[00075] After the user takes the mixed medicine as described above into syringe 2, the user can separate syringe 2 from the connection device 1, connect the cannula to the perforation for the syringe, and administer the medicine to a patient using syringe 2.
[00076] When the syringe 2 is separated from the connection device 1, the cannula retaining member 7 is located in the forward position, and the partial thread portions 42b of the separation prevention means 42 are continuous with the internal thread portion 32a of the syringe retaining member 6.
[00077] As a result, partial thread portions 42b do not interfere with outer thread portion 12c of syringe 2, and thus rotation of syringe 2 and syringe retaining member 6 can be allowed, and syringe 2 can be separated.
[00078] On the other hand, when the cannula retaining member 7 is located in the forward position, the stop members 42c pass over the wide diameter portion 13b of the cap member 13 in the syringe 2 while being deformed and engage the portion of wide diameter 13b on the side Next to syringe 2.
[00079] As a result, when syringe 2 is separated from the
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15/25 syringe retaining member 6, the cap member 13 can be removed from syringe 2 by engaging it with the syringe retaining member 6 being held by the stop members 42c.
[00080] As described above, according to the connection device 1 fr a first embodiment, since the partial thread portions 42b of the separation prevention means 42 engage the external thread portion 12c of the syringe 2 in the pre-condition syringe 2 cannot be removed from connection device 1.
[00081] Hereinafter, when communication is established between the inner spaces of the syringe 2 and the vial as the state of use, partial thread portions 42b are aligned with the inner thread portion 32a of the syringe retaining member 6 for allow rotation of the external thread portion 12c, and thus the syringe 2 can be separated from the connection device 1.
[00082] That is, according to connection device 1 of a first embodiment, connection device 1 is designed such that syringe 2 cannot be separated in a state in which no communication is established between syringe 2 and the vial 3. Therefore, the connection device 1 can prevent an error by the user, and prevent the user from forgetting to carry out an operation to establish communication between the syringe 2 and the vial 3.
[00083] In the following, a connection device 101 according to a second mode will be described. Figure 6 shows a cross-sectional view of the connection device 101 according to the second embodiment, and figure 7 is a view illustrating a method of using the connection device 101.
[00084] In the following description, parts common to those in a first modality will not be repeatedly described, and identical members will be designated by the numerals given by the addition of 100
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16/25 to the numerals used in a first modality.
[00085] A connection portion 112 of a syringe 102 is composed of a hollow tapered portion 112a in communication with the interior of a barrel not shown, and a cylindrical portion 112b provided to surround the tapered portion 112a. An internal thread portion 112c is formed at an inner periphery of the cylindrical portion 112b.
[00086] In addition, engagement grooves 112d are formed on an outer peripheral surface of the cylindrical portion 112b in the forward-backward direction, in opposite positions with the central axis being interspersed between them. Coupling grooves 112d are formed to be opened at an end portion of the cylindrical portion 112b.
[00087] Additionally, a thin rubber plate type cap member 113 is attached to a tip end of the tapered portion 112a, and is sandwiched between the tip end and a syringe retaining member 106.
[00088] Retention means 104 is composed of the syringe retention member 106 to be connected to the syringe 102, and a cannula retention member 107 that includes the double head cannula 105. The syringe retention member 106 and the cannula retaining member 107 are provided to be able to be advanced and retracted.
[00089] The penetration holes 131a are formed in opposite positions on an outer cylindrical portion 131 of the syringe retaining member 106. Additionally, on an inner peripheral surface of the outer cylindrical portion 131, stop projections 135 in an arc shape are formed, and guide projections 134 not shown are formed in the forward-delayed direction.
[00090] The connecting portion 132 is formed in the shape of a cylinder, its outer peripheral surface has a diameter substantially identical to that of an inner peripheral surface of the cylindrical portion
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17/25
112b in the connection portion 112 of the syringe 102, and its inner peripheral surface has a larger diameter than that of the tapered portion 112a.
[00091] In addition, an outer thread portion 132a that must be screwed into the inner thread portion 112c formed in the cylindrical portion 112b is formed on the outer peripheral surface of the connecting portion 132.
[00092] Furthermore, a cylindrical support portion 136 formed to have a diameter larger than that of the cylindrical portion 112b of syringe 102 is formed still outside of the connecting portion 132. The supporting portion 136 has a delayed portion formed as a thick portion 136a, and an advanced portion formed as a thin portion 136b.
[00093] The thick portion 136a is located such that when the syringe 102 is attached to the syringe retaining member 106, the thick portion 136a reaches a position identical to a position where a tip end portion of the cylindrical portion 112b of the syringe 102 arrives. In this way, a step difference between the thick portion 136a and the thin portion 136b is formed on an internal peripheral surface of the support portion 136.
[00094] On an outer peripheral surface of an inner cylindrical portion 141 on the cannula retaining member 107, guide grooves not shown in which the guide projections of the outer cylindrical portion 131 will engage are formed to restrict rotation of the syringe retaining member 106 and the cannula retaining member 107.
[00095] Additionally, on the outer peripheral surface of the inner cylindrical portion 141, stop grooves 144 in which each stop projection 135 of the outer cylindrical portion 131 will engage are formed in two positions in the forward-backward direction. Stop grooves
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18/25
144 will allow the cannula retaining member 107 to stop in the second retracted position and in a first retracted position with respect to the syringe retaining member 106.
[00096] Furthermore, in the inner cylindrical portion 141, flaps 141a are formed to be aligned with the positions of the penetration holes 131a formed in the outer cylindrical portion 131, and retaining projections 145 which will engage a ring member 123 of the flask 103 are formed on the inner surfaces of the flaps 141a.
[00097] The separation prevention means 142 is provided for the cannula retaining member 107, and is composed of two deformation portions 142a provided in opposite positions with the cannula on the syringe side 5a being interspersed between them, and protrusions of engagement 142b provided on the inner sides of the tip ends of the deformation portions 142a.
[00098] Deformation portions 142a are provided to penetrate the bottom portion of the syringe retaining member 106 and project towards the connecting portion 132, and are provided to contact an inner peripheral surface of the thick portion 136a of the support portion 136.
[00099] In addition, engagement protrusions 142b are provided in positions where they engage engagement grooves 112d formed in syringe 102 in a pre-use state in which syringe 102 is attached to syringe retaining member 106.
[000100] Hereinafter, a method of using connection device 101 having the above configuration will be described with reference to the drawings in figure 7.
[000101] First, Figure 7 (a) shows a state of assembly of the connection device 101, in which the cannula retaining member 107 is stopped in the second retracted position with respect to the syringe retaining member 106.
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19/25 [000102] On this occasion, the guide projections of the outer cylindrical portion 131 are forced to engage the guide grooves in the inner cylindrical portion 141, and thus the rotation of the syringe retaining member 106 and the cannula retaining member 107 is restricted.
[000103] On the other hand, when the cannula holding member 107 is located in the second retracted position, deformation portions 142a of the separation prevention means 142 project between the connecting portion 112 of the syringe holding member 106 and the support portion 136, and stop at positions where the portions having engagement protrusions 142b formed there do not move beyond the thick portion 136a.
[000104] Next, figure 7 (b) shows a connection state in which the syringe 102 is connected to the connection device 101, in which the external thread portion 132a of the syringe retaining member 106 is screwed into the portion internal thread 112c of syringe 102.
[000105] Thus, the tip end portion of the cylindrical portion 112b of syringe 102 is located at a boundary between the thin portion 136b and the thick portion 136a of the support portion 136, and engagement grooves 112d are located at angles in the which the hitch projections 142b are located.
[000106] On this occasion, coupling projections 142b are stopped at the position of the thick portion 136a, and do not engage in the coupling grooves 112d. Therefore, hand lugs 142b prevent rotation of the syringe 102.
[000107] Next, figure 7 (c) shows the pre-use state, and illustrates a state in which the cannula retaining member 107 is advanced to the first retracted position, and the flask 103 is fitted to the cannula retention 107.
[000108] In this way, the double head cannula 105 approaches the cap member 113 of the syringe 102 to a position where it does not
Petition 870190102962, of 10/14/2019, p. 22/39
20/25 penetrate the cap member 113, and the engagement projections 142b of the separation prevention means 142 are advanced and engage the engagement grooves 112d on the syringe retaining member 106.
[000109] Here, the rotation of the cannula holding member 107 and the syringe holding member 106 is restricted by the guide bosses 134 and guide grooves 143, and the rotation of the syringe 102 and syringe holding member 106 is also restricted. . Thus, syringe 102 cannot be separated from syringe retaining member 106.
[000110] Furthermore, although the hitch projections 142b are advanced and protrude more than the thick portion 136a of the support portion 136, they protrude from the thick portion 136a only in a small amount. Consequently, if an attempt is made to rotate the syringe 102 and the syringe retaining member 106, the thick portion 136a prevents deformation of the deformation portions 142a, and prevents the engagement projections 142b from being detached from the engagement grooves 112d.
[000111] Additionally, since vial 103 abuts the retaining projections 145 of the rear cannula retention member 107, vial 103 is kept in a state where it is close to a cannula on the side of vial 105b of the cannula. double head 105.
[000112] Next, Figure 7 (d) shows a penetrated state on the syringe side in which only the cannula on the syringe side 105a of the double head cannula 105 penetrates the cap member 113 of syringe 102. [000113] How in a first embodiment, the cannula on the syringe side 105a of the present embodiment is also thinner and has less puncture resistance than the cannula on the side of vial 105b and the resistive force that allows vial 103 to pass over the protrusions of 145 retention is required. Consequently, the cannula retaining member 107 first moves to an advanced position with respect to the syringe retaining member 106,
Petition 870190102962, of 10/14/2019, p. 23/39
21/25 and the syringe side cannula 105a penetrates the cap member 113 of syringe 102.
[000114] Subsequently, Figure 7 (e) shows a state of use in which syringe 102 and vial 103 are placed close together.
[000115] When vial 103 is further advanced from the penetrated state on the side of the syringe in Figure 7 (d), vial 103 presses out the retaining projections 145, and thus the flaps 141a of the cannula retaining member 107 are deformed while projecting out of the penetration orifices 131a formed in the outer cylindrical portion 131 of the syringe retaining member 106, to allow passage of the vial 103.
[000116] Next, the flask 103 is advanced and touches the inner cylindrical portion 141 of the cannula retaining member 107. Thus, the flask 103 is held in the cannula retaining member 107 by the retaining projections 145.
[000117] On the other hand, as the vial 103 is advanced, the cannula on the vial side 105b of the double head cannula 105 penetrates the cap member 122 of vial 103, and thus communication is established between an internal space syringe 102 and an internal space of vial 103.
[000118] After entering the state of use, a drug in vial 103 is dissolved with a solution in syringe 102, and the obtained drug is taken into syringe 102. Then, syringe 102 can be separated from the connection device 101 , as in a first modality.
[000119] Specifically, when positioning the cannula retaining member 107 in the forward position as the state of use, engagement protrusions 142b of the separation prevention means 142 move in front of the engagement grooves 112d on the syringe retaining member
Petition 870190102962, of 10/14/2019, p. 24/39
22/25
106, advance over the outer peripheral surface of the cylindrical portion 112b, and move outward.
[000120] On this occasion, since the deformation portions 142a are advanced from the thick portion 136a towards the thin portion 136b of the support portion 136, the deformation portions 142a are deformed according to the movement of the engaging projections 142b, and the thin portion 136b allows the movement of the engaging projections 142b and the deformation of the deformation portions 142a.
[000121] Since the engagement protrusions 142b are separated from the engagement grooves 112d as described above, the syringe 102 can be rotated with respect to the syringe retaining member 106, and thus the syringe 102 can be separated.
[000122] As described above, according to the connection device 101 of the second embodiment, since the engagement projections 142b of the separation prevention means 142 engage the engagement grooves 112d of the syringe 102 in the pre-use state for prevent rotation of syringe 102 and connecting device 101, syringe 102 cannot be removed.
[000123] Hereinafter, when communication is established between the internal spaces of the syringe 102 and the vial 103 as the state of use, latch protrusions 142b are separated from the latch slots 112d to allow rotation of the syringe 102 and the member syringe holder 106, and thus syringe 102 can be separated from the connection device 101.
[000124] That is, also in connection device 101 of the second embodiment, connection device 101 is designed such that syringe 102 cannot be used in a state where no communication is established between syringe 102 and vial 103, as in connection device 1 of a first embodiment. In this way, connection device 101 can prevent an error by the user, and prevent
Petition 870190102962, of 10/14/2019, p. 25/39
23/25 the user forgets to perform an operation to establish communication between the syringe 102 and the vial 103.
[000125] Figure 8 shows a cross-sectional view of a connection device 201 according to a third embodiment, which is suitable for storage in a freeze-dried medicine bottle, when compared to connection device 1 of a first modality.
[000126] In the following description, parts common to those in a first modality will not be repeatedly described, and identical members will be designated by the numerals given by adding 200 to the numerals used in a first modality.
[000127] Generally, the inside of a bottle that stores a freeze-dried medicine is kept under a vacuum. When the first mode connection device 1 is used to enter the state of use shown in figures 4 (e) and 5 (e), a problem occurs that, although the solution inside the syringe 2 is carried into the bottle 3 by a pressure difference, the pressure difference makes a plunger retract operation heavier when the medicine inside the vial 3 is thus brought into the syringe 2.
[000128] Therefore, connection device 201 of the third embodiment is configured by providing connection device 1 of a first embodiment with an opening 241b in a side surface of an inner cylindrical portion 241 of a cannula holding member 207, and a filter 246 provided for opening 241b.
[000129] Aperture 241b is formed within a cylindrical housing 241c formed from an outer periphery of the inner cylindrical portion 241 to a cannula on the side of the vial 205b. In the state of use, the vial is held in the cannula retaining member 207 in a state that abuts housing 241c from below.
Petition 870190102962, of 10/14/2019, p. 26/39
24/25 [000130] Additionally, two channels 205c are formed within the cannula on the side of the vial 205b. One channel 205c is in communication with the cannula on the side of syringe 205a, and the other channel 205c is in communication with opening 241b.
[000131] In addition, communication holes 231b are formed in an outer cylindrical portion 231 of a syringe holding member 206. When the cannula holding member 207 is advanced with respect to the syringe holding member 206 as the state of In use, opening 241b overlaps communication hole 231b.
[000132] With such a configuration, when the connection device 201 is forced to enter the state of use by an operation identical to that in connection device 1 according to a first modality, the solution inside the syringe is taken into the bottle by a pressure difference due to the interior of the bottle being kept under a vacuum.
[000133] On this occasion, since the cannula holding member 207 is advanced with respect to the syringe holding member 206 and the opening 241b overlaps the communication port 231b, the external air is drawn from the opening 241b into the vial through the communication port 231b, and the inside of the bottle has common pressure.
[000134] On this occasion, the air taken passes through the filter 246, and the dust, microorganisms, and the like in the air are caught by the filter 246 to prevent them from entering the flask.
[000135] When the medicine is prepared inside the bottle and here after the syringe plunger is retracted to take the medicine into the syringe, the plunger can be retracted with no resistance, because air is supplied into the bottle through opening 241b and so the inside of the bottle does not have a negative pressure.
[000136] It should be noted that aperture 241b and the configuration related to it in the third modality are also applicable to
Petition 870190102962, of 10/14/2019, p. 27/39
25/25 connection device 101 in the second mode. INDUSTRIAL APPLICABILITY [000137] In the present invention, in the pre-use state, the separation prevention means prevents the syringe from being separated from the syringe retaining member, as described above. In this way, the connecting device can prevent a user from forgetting to perform an operation to establish communication between the syringe and the vial, and thus can be used appropriately for medical care. REFERENCE SIGNAL LISTING [000138] 1: connecting device, 2: syringe, 3: vial, 4: double-head cannula, 6: syringe-holding member, 7: cannula-holding member , 12: connection portion, 12c: external thread portion, 12d: groove, 32: connection portion, 32a: internal thread portion, 32b: groove, 42: separation prevention means, 42b: partial thread portion, 45: retaining projection.

权利要求:
Claims (9)
[1]
1. Connection device (1, 101, 201), comprising:
the retention means (4, 104) away from a syringe (2, 102) and a vial (3, 103) from each other or by placing the syringe (2, 102) and the vial (3, 103) close to each other; and a double head cannula (5, 105, 205) provided between the cap members (13, 22, 113, 122) connected to a syringe (2, 102) and the vial (3, 103) to penetrate the members of cap, the connection device (1, 101, 201) changing from a pre-use state in which the holding means (4, 104) distances the syringe (2, 102) and the vial (3, 103) one from the another and the double-head cannula (5, 105, 205) does not penetrate the cap members (13, 22, 113, 122) of a syringe (2, 102) and a vial (3, 103), until a state for use in which the retention medium (4, 104) places a syringe (2, 102) and the vial (3, 103) next to each other and the double-headed cannula (5, 105, 205) penetrates the limbs of cap (13, 22, 113, 122) of a syringe (2, 102) and vial (3, 103) to establish communication between the internal spaces of a syringe (2, 102) and the vial (3, 103), characterized by the fact that the holding means (4, 104) is composed of a syringe holding member (6, 106, 206) as er attached to the syringe (2, 102), and a cannula retaining member (7, 107, 207) that includes the double-head cannula (5, 105, 205), is located in a retracted, retracted position with respect to the syringe retaining member (6, 106, 206) in the pre-use state, and is advanced to an advanced position by touching the syringe retaining member (6, 106, 206) in the use state, the means of preventing separation (42, 142) engaging the syringe (2, 102) to prevent separation of the syringe (2, 102) from the syringe retaining member (6, 106, 206) in the state where the member
Petition 870190102962, of 10/14/2019, p. 29/39
[2]
2/6 cannula retention (7, 107, 207) is located in the retracted position is still provided, and when the cannula retention member (7, 107, 207) is located in the forward position, the means of preventing separation (42, 142) releases a state of engagement with the syringe (2, 102) to allow separation of the syringe (2, 102) from the syringe retaining member (6, 106, 206).
2. Connection device (1, 101, 201) according to claim 1, characterized in that the syringe retaining member (6, 106, 206) and the syringe (2, 102) are connected by screwing, and the separation prevention means (42, 142) is provided for the cannula retaining member (7, 107, 207), and when the cannula retaining member (7, 107, 207) is located in the retracted position on the pre-use state, the separation prevention means (42, 142) engages the syringe (2, 102) to prevent rotation of the syringe (2, 102) and the syringe retaining member (6, 106, 206) , and when the cannula retaining member (7, 107, 207) is located in the advanced position in the state of use, the separation prevention means (42, 142) releases the engagement state to allow rotation of the syringe (2 , 102) and the syringe retaining member (6, 106, 206).
[3]
Connection device (1, 101, 201) according to claim 2, characterized in that an external thread portion (12c, 112c) is formed in the syringe (2, 102), and an internal thread portion (32a, 132a), in which the external thread portion (12c, 112c) is to be screwed, is formed in the syringe retaining member (6, 106, 206), grooves (12d, 32b) are formed in the thread portion (12c, 112c) and the internal thread portion (32a, 132a), respectively, in a direction in which the
Petition 870190102962, of 10/14/2019, p. 30/39
3/6 first (6, 106, 206) and second (7, 107, 207) retaining members are advanced and retracted, and the grooves (12d, 32b) are provided in positions where the grooves (12d, 32b) will overlap when the outer thread portion (12c, 112c) is screwed into the inner thread portion (32a, 132a), the separation prevention means (42, 142) is made up of an insert (42a, 142a) provided for the cannula retaining member (7, 107, 207) to be advanced and retracted along with the groove (32b), and a partial thread portion (42b) protruding from the insert (42a, 142a) towards the syringe ( 2, 102), in the pre-use state, the partial thread portion (42b) is located in a misaligned position with respect to a helical shape of the internal thread portion (32a, 132a), and engages the portion of external thread (12c, 112c) to prevent rotation of the syringe (2, 102) and syringe retaining member (6, 106, 206), and in the state of use, the portion Partial thread (42b) is aligned with the helical shape of the internal thread portion (32a, 132a), and releases a state of engagement between the partial thread portion (42b) and the external thread portion (12c, 112c) to allow rotation of the syringe (2, 102) and the syringe retaining member (6, 106, 206).
[4]
Connecting device (1, 101, 201) according to claim 3, characterized in that the cannula retaining member (7, 107, 207) is provided to be movable to a second retracted position which is more retracted with respect to the syringe retaining member (6, 106, 206) than the retracted position, and when the connecting device (1, 101, 201) is attached to the syringe (2, 102), the cannula (7, 107, 207) is located in the second retracted position, and the partial thread portion (42b) in the separation prevention means (42, 142) is located in
Petition 870190102962, of 10/14/2019, p. 31/39
4/6 a retracted position towards the vial (3, 103) of the internal thread portion (32a, 132a) of the syringe retaining member (6, 106, 206) to allow rotation of the syringe (2, 102) and of the syringe retaining member (6, 106, 206).
[5]
Connecting device (1, 101, 201) according to claim 3 or 4, characterized in that a large diameter portion (13b) is formed in the syringe cap member (2, 102), and a stop member (42c) projecting towards a center is provided for the insert (42a, 142a) in a position closer to the vial (3, 103) than the partial thread portion (42b), and in the after use, the stop member (42c) engages the wide diameter portion (13b) of the cap member (13, 113) on the side closest to the syringe (2, 102).
[6]
Connecting device (1, 101, 201) according to claim 2, characterized in that a cylindrical portion (12b, 112b) is formed at one end of the syringe tip (2, 102) and a portion of internal thread (32a, 132a) is formed within the cylindrical portion (12b, 112b), and an external thread portion (12c, 112c) to be inserted into the cylindrical portion (12b, 112b) and screwed into the internal thread portion (32a , 132a) on the outside is formed in the syringe retaining member (6, 106, 206), an engagement groove (112d) is formed on an external surface of the cylindrical portion (12b, 112b) of the syringe (2, 102) , and the syringe retaining member (6, 106, 206) and the cannula retaining member (7, 107, 207) are made non-rotatable with respect to each other, the separation prevention means (42, 142) is composed of a deformation member which is provided for the cannula retaining member (7, 107, 207) and located further outside r than the portion
Petition 870190102962, of 10/14/2019, p. 32/39
5/6 cylindrical (12b, 112b), and a hitch protrusion (142b) which is provided for the deformation member and can engage the hitch groove (112d), in the pre-use state, the hitch protrusion (142b ) engages the engagement groove (112d) to prevent full rotation of the syringe retaining member (6, 106, 206) and the cannula retaining member (7, 107, 207) with respect to the syringe (2, 102) , and when the cannula retaining member (7, 107, 207) is located in the forward position in the state of use, the engagement protrusion (142b) is advanced and separated from the engagement groove (112d) while deforming the deformation portion to allow full rotation of the syringe retaining member (6, 106, 206) and the cannula retaining member (7, 107, 207) with respect to the syringe (2, 102).
[7]
Connecting device (1, 101, 201) according to claim 6, characterized in that the cannula retaining member (7, 107, 207) is provided to be movable to a second retracted position which is more retracted with respect to the syringe retaining member (6, 106, 206) than the retracted position, and when the connecting device (1, 101, 201) is attached to the syringe (2, 102), the cannula (7, 107, 207) is located in the second retracted position, and the engagement protrusion (142b) in the separation prevention means (142) is located in a retracted position towards the vial (3, 103) of the engaging (112d) the syringe retaining member (6, 106, 206) to allow rotation of the syringe (2, 102) and syringe retaining member (6, 106, 206).
[8]
Connecting device (1, 101, 201) according to claim 6 or 7, characterized in that a support portion (136) formed to contact
Petition 870190102962, of 10/14/2019, p. 33/39
6/6 with an additional outer periphery of the deformation portion of the cannula retaining member (7, 107, 207) is provided for the syringe retaining member (6, 106, 206), in the pre-use state, the support portion (136) is in close contact with the deformation portion to a position of the engaging protrusion (142b), and prevents deformation of the deformation portion to prevent separation of the engaging protrusion (142b) from the engaging groove ( 112d) in the syringe (2, 102), and in the state of use, the coupling boss (142b) is advanced, separated from the coupling groove (112d) in the syringe (2, 102), and moves to one side of the periphery external, and the support portion (136) allows the deformation portion to be deformed due to the movement of the engagement protrusion (142b).
[9]
Connecting device (1, 101, 201) according to any one of claims 1 to 8, characterized in that the cannula retaining member (7, 107, 207) is provided with a plurality of tabs (41a , 141a) provided to surround the vial (3, 103), and the retaining projections (45, 145) projecting over the inner sides of the flaps (41a, 141a), and in the pre-use state, an end surface of the vial (3, 103) on a side next to the syringe (2, 102) touches the rear ends of the retaining projections (45, 145), and in the state of use, the vial (3, 103) passes over the projections of retention (45, 145) while deforming the flaps (41a, 141a), and the retaining protrusions (45, 145) engage a flange (21a) formed in the vial (3, 103) to retain the vial (3, 103).

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同族专利:

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法律状态:
2019-01-15| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|

2019-07-16| B06A| Patent application procedure suspended [chapter 6.1 patent gazette]|

2020-02-04| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|

2020-04-07| B16A| Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 12/07/2010, OBSERVADAS AS CONDICOES LEGAIS. |

优先权:

申请号 | 申请日 | 专利标题

JP2009166867A|JP5333850B2|2009-07-15|2009-07-15|Connecting device|

PCT/JP2010/061778|WO2011007760A1|2009-07-15|2010-07-12|Connection device|

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